SYNTHESIS, SPECTRAL CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF SOME SCHIFF BASES OF 4-CHLORO-2-AMINOPHENOL


Cinarli A. , Gurbuz D., Tavman A. , Birteksoz A. S.

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, cilt.25, ss.407-417, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 25 Konu: 3
  • Basım Tarihi: 2011
  • Dergi Adı: BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
  • Sayfa Sayıları: ss.407-417

Özet

A series of 4-chloro-2-[(arylmethylidene)amino] phenols (1-11) including methoxy group were synthesized using appropriate synthetic route. The structures of the Schiff bases were characterized by FT-IR, UV-Vis, ESI-MS, H-1 and C-13-NMR spectroscopic techniques and analytical methods. A relation is observed between melting points and existence of intramolecular hydrogen bonding. IR spectra of the compounds including and not including hydrogen bonding were compared. The compounds 2 and 4 show the characteristic UV bands attributed to the NH-forms. According to the H-1-NMR spectral data the compound 2 has the strongest intramolecular hydrogen bonding and the compound 6 shows two isomeric structure. On the other hand, antibacterial and antifungal activities of the compounds were investigated. Most of the compounds show selective activity toward S. epidermidis and C. albicans.