Long-Term Impact of Different Immunosuppressive Drugs on QT and PR Intervals in Renal Transplant Patients


Ikitimur B. , Cosansu K. , Karadag B. , Cakmak H. A. , Avci B. , Erturk E., ...More

Annals of Noninvasive Electrocardiology, vol.20, no.5, pp.426-432, 2015 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.1111/anec.12225
  • Title of Journal : Annals of Noninvasive Electrocardiology
  • Page Numbers: pp.426-432

Abstract

© 2014 Wiley Periodicals, Inc.Background Sudden cardiac deaths due to arrhythmias are thought to be an important cause of mortality in patients with renal transplants. Exposure to immunosuppressive drugs may lead to QT or PR interval abnormalities which may consequently cause arrhythmias. Our study investigated the long term impact of four different immunosuppressive drugs on PR and corrected QT intervals (QTc) in renal transplant patients Methods The study population consisted of 98 kidney transplant recipients. Study patients were receiving immunosuppressive management with tacrolimus, cyclosporine A, everolimus or azathioprine according to the local protocols. QTc and PR intervals obtained from the most recent post-transplant electrocardiograms were compared with the pre-transplant intervals dated before the transplantation procedure. Results Post-transplant QTc intervals had prolonged significantly in comparison to the pre-transplant QTc intervals in all groups. However, there were no significant differences between the immunosuppressive agents with regard to post-transplant QTc interval prolongation (p > 0.05). There were no significant differences between the groups with regard to the pre and post-transplant PR interval changes (p > 0.05). Conclusions QT interval prolongation, a marker of risk for arrhythmias and sudden death, is highly prevalent among kidney transplant patients receiving different classes of immunosuppressive drugs.