The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy


Gulcebi M. I. , Ozkaynakci A., GÖREN M. Z. , Aker R. G. , Ozkara C. , Onat F. Y.

EPILEPSY RESEARCH, cilt.95, ss.1-8, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.eplepsyres.2011.01.016
  • Dergi Adı: EPILEPSY RESEARCH
  • Sayfa Sayıları: ss.1-8

Özet

Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.