Respiratory alterations due to chronic long-term intermittent hypobaric hypoxia in rabbits: Importance of peripheral chemoreceptors


Guner I. , Yelmen N. , Sahin G., Oruç T., Sipahi S., Yaman M. O.

ARCHIVES OF MEDICAL RESEARCH, vol.38, no.7, pp.739-745, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 7
  • Publication Date: 2007
  • Doi Number: 10.1016/j.arcmed.2007.04.010
  • Title of Journal : ARCHIVES OF MEDICAL RESEARCH
  • Page Numbers: pp.739-745

Abstract

Background. None of the studies carried out so far investigated the effect of denervation of peripheral chemoreceptors on basal ventilation and respiratory responses to acute hypoxia in subjects exposed to chronic long-term intermittent hypobaric hypoxia (CLTIHH). We aimed to research (i) the effect of CLTIHH (430 mmHg, 5 h/day, 5 days/week, 5 weeks) on basal ventilation and respiratory responses to hypoxia and (ii) the effects of CLTIHH on central respiratory mechanisms after peripheral chemodenervation.