Subclinic arterial and left ventricular systolic impairment in autosomal dominant polycystic kidney disease with preserved renal functions


AKPINAR T. S. , Kucukdagli P., Ozer P. K. , KARAAYVAZ E. B. , İNCE B., Bakkaloglu O. K. , ...More

INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.1007/s10554-021-02389-8
  • Title of Journal : INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • Keywords: Polycystic kidney, Arterial stiffness, Carotid intima-media, Global longitudinal strain, GROWTH-FACTOR 23, ENDOTHELIAL DYSFUNCTION, STIFFNESS, FIBROBLAST-GROWTH-FACTOR-23, HYPERTROPHY, PROGRESSION

Abstract

Subclinical atherosclerosis and cardiovascular events are common even in young normotensive patients with autosomal dominant polycystic kidney disease (ADPKD). Our aim was to examine the relationship between serum fibroblast growth factor-23 (FGF-23) levels, left ventricular global longitudinal strain (LV-GLS), arterial stiffness (AS), and carotid intima-media thickness (CIMT) in patients with ADPKD with preserved kidney function. The relationship between albuminuria, AS, LV-GLS, CIMT, 24-hour ambulatory blood pressure measurement, and FGF-23 was examined in 52 normotensive and hypertensive patients with ADPKD and a matched control group of 35 subjects. AS was assesed with brachial-ankle pulse wave velocity, LV-GLS was measured with speckle-tracking echocardiography. FGF-23 was measured with enzyme-linked immunosorbent assay. The microalbumin/creatinine ratio was significantly higher in the ADPKD group than in the control group (p?