Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Metastatic Urothelial Carcinoma Patients Treated With First-line Chemotherapy: A Large Multicenter Study


Auvray M., Elaidi R., Ozguroglu M. , Guven S., Gauthier H., Culine S., ...More

CLINICAL GENITOURINARY CANCER, vol.15, no.3, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1016/j.clgc.2016.10.013
  • Title of Journal : CLINICAL GENITOURINARY CANCER

Abstract

This multicenter study assessed the prognostic value of the neutrophile-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation, for overall survival (OS) and progression-free survival (PFS) after first-line chemotherapy (CT) in 280 metastatic urothelial cancer patients. High pre-CT NLR was an independent predictor of reduced of OS (hazard ratio=1.36; P<.0001), highlighting the importance of an inflammatory cancer-related microenvironment.