Familial hypercholesterolaemia and early coronary artery disease: A case report and review of the literature


Gündüz H., Arinç H., Yolcu M., Kayardi M., ÖZYILDIRIM S. , Ergüzel N., ...More

Turkiye Klinikleri Journal of Medical Sciences, vol.26, no.5, pp.565-568, 2006 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Review
  • Volume: 26 Issue: 5
  • Publication Date: 2006
  • Title of Journal : Turkiye Klinikleri Journal of Medical Sciences
  • Page Numbers: pp.565-568

Abstract

Familial hypercholesterolaemia (FH) is an important public health problem due to the high incidence of premature coronary artery disease leading to a reduction in life expectancy, observed in many families with FH. It is an autosomal dominant disorder caused by mutations of the LDL receptor gene. FH heterozygotes have approximately twice the normal LDL-cholesterol concentration in early childhood, and have increased risk of early myocardial infarction. In this report, a 21-year-old male patient with FH type IIa who was referred to our hospital with a diagnosis of non-Q myocardial infarction, and who underwent subsequent coronary bypass grafting after coronary angiography, was presented. Copyright © 2006 by Türkiye Klinikleri.