SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus

Caliskan Z., Mutlu T., Guven M., Tuncdemir M., Niyazioglu M., Hacioglu Y., ...More

GENE, vol.642, pp.542-548, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 642
  • Publication Date: 2018
  • Doi Number: 10.1016/j.gene.2017.11.071
  • Title of Journal : GENE
  • Page Numbers: pp.542-548


Sirtuins (SIRTs) is a family of NAD+ dependent histone deacetylases. SIRT6 takes play in glucose homeostasis, genomic stability and DNA repair. Although increased oxidative DNA damage and decreased DNA repair activity were determined in diabetes mellitus, the possible relation between level of oxidative DNA damage and SIRT6 expression has not been investigated so far. We determined SIRT6 expression and urinary 8-hydroxy deoxyguanosine (8-OHdG) levels, marker of oxidative DNA damage, in cases with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM).