Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood


KÜÇÜKSEZER U. C. , Palomares O., Rueckert B., Jartti T., Puhakka T., Nandy A., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.131, no.3, pp.875-894, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jaci.2012.10.051
  • Title of Journal : JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Page Numbers: pp.875-894

Abstract

Background: The generation and maintenance of allergen-specific T-cell tolerance is a key step in healthy immune responses to allergens and successful allergen-specific immunotherapy. Breaking of peripheral T-cell tolerance to allergens can lead to the development of allergies, but the mechanisms are not completely understood.