The association of genetic polymorphisms of bone formation genes with canine hip dysplasia

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Akış Akad I. , Ateş A. , Atmaca G. , Öztabak K. Ö. , Esen Gürsel F. , Yardibi H. , ...Daha Fazla

Iranian Journal Of Veterinary Research, cilt.21, ss.40-45, 2020 (SCI Expanded İndekslerine Giren Dergi)

  • Cilt numarası: 21
  • Basım Tarihi: 2020
  • Doi Numarası: 10.22099/ijvr.2019.31251.4713
  • Dergi Adı: Iranian Journal Of Veterinary Research
  • Sayfa Sayıları: ss.40-45


Background: Canine hip dysplasia (CHD) is an orthopedic disorder characterized by abnormal laxity of the hip joint. It is

considered multifactorial and polygenic and affects predominantly medium and large sized dog breeds. Aims: The aim of this study

was to identify CHD associated polymorphisms in chromosomal regions on CFA19, CFA24, CFA26, and CFA34. Methods: Blood

samples from 60 dogs of different breeds were collected and genotyped, including 46 cases and 14 controls. After sequencing and

single nucleotide polymorphism (SNP) determination of the target regions, an individual SNP analysis with a 2 statistic was

performed based on the comparison of allele frequencies in cases and controls. Results: A significant association was observed

between CHD and a T/C SNP on CFA19, which harbors genes involved in bone metabolism. No other significant association was

found in the study and previously identified SNPs cannot be validated as related to CHD. Conclusion: Further research is warranted to

identify CHD-associated polymorphisms in order to develop a genotype-based diagnosis and selection approach.