EC Dental Science, cilt.9, sa.17, ss.1508-1514, 2018 (Diğer Kurumların Hakemli Dergileri)
Background: Dentifrices from the most commonly used chemotherapeutic agents in daily plaque controlare capable of preventing
bacterial adhesion, colonization and metabolism, and thus affect the bacterial growth.
Keywords: Toothpaste; Streptococcus mutans; Streptococcus sobrinus; Lactobacillus casei; Actinomyces naeslundii; Candida albicans
Aim: The aim of this in vitro study is to investigate the antibacterial effects of the fluoride gels and kinds of toothpaste with fluoride
Methods: Six kinds of toothpaste for children (3 nonfluoride and 3 fluoride) were tested for their antibacterial activity against
five oral pathogens; Streptococcus mutans (ATCC 25175), Streptococcus sobrinus (ATCC 33478), Lactobacillus casei (ATCC 4646),
Actinomyces naeslundii (ATCC 19039) and Candida albicans (ATCC 10231) by agar well diffusion assay and two fluoride gels were
also tested by disc diffusion assay. Data were analyzed statistically by using Kruskal Wallis and Mann Whitney U tests. Test with a
significance level of p < 0.05.
Results: Group I fluoride toothpaste was found statistically effective against only C. albicans (p < 0.01). Group II and III fluoride
toothpaste were found statistically effective against all tested oral pathogens (p < 0.05). Group IV nonfluoride toothpaste was found
statistically effective against C. albicans, S. sobrinus, L. casei (p < 0.01). Group V nonfluoride toothpaste was found statistically effective
against S. mutans, S. sobrinus, L. casei and A. naeslundii (p < 0.05). Group VI nonfluoride toothpaste was found ineffective against
all tested oral pathogens (p > 0.05). Group VII fluoride gel was found less effective C. albicans and S. sobrinus (p < 0.05). But Group
VIII zinc fluoride gel was found statistically ineffective against all tested oral pathogens (p > 0.05).
Conclusion: Despite gels were found ineffective in this in vitro study, they will be given more positive results in clinical usage and in
vivo studies. In vivo studies should be performed to investigate the antibacterial effects of toothpastes and fluoride gels.