Investigation of the In Vitro Antibacterial Effects of Different Toothpastes and Fluoride Gels: An In Vitro Study


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Birant S. , Koruyucu M., Topcuoğlu E. N. , Külekçi H. G. , Seymen F.

EC Dental Science, cilt.9, sa.17, ss.1508-1514, 2018 (Diğer Kurumların Hakemli Dergileri)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Konu: 17
  • Basım Tarihi: 2018
  • Dergi Adı: EC Dental Science
  • Sayfa Sayıları: ss.1508-1514

Özet

Background: Dentifrices from the most commonly used chemotherapeutic agents in daily plaque controlare capable of preventing

bacterial adhesion, colonization and metabolism, and thus affect the bacterial growth.

Keywords: Toothpaste; Streptococcus mutans; Streptococcus sobrinus; Lactobacillus casei; Actinomyces naeslundii; Candida albicans

Aim: The aim of this in vitro study is to investigate the antibacterial effects of the fluoride gels and kinds of toothpaste with fluoride

and nonfluoride.

Methods: Six kinds of toothpaste for children (3 nonfluoride and 3 fluoride) were tested for their antibacterial activity against

five oral pathogens; Streptococcus mutans (ATCC 25175), Streptococcus sobrinus (ATCC 33478), Lactobacillus casei (ATCC 4646),

Actinomyces naeslundii (ATCC 19039) and Candida albicans (ATCC 10231) by agar well diffusion assay and two fluoride gels were

also tested by disc diffusion assay. Data were analyzed statistically by using Kruskal Wallis and Mann Whitney U tests. Test with a

significance level of p < 0.05.

Results: Group I fluoride toothpaste was found statistically effective against only C. albicans (p < 0.01). Group II and III fluoride

toothpaste were found statistically effective against all tested oral pathogens (p < 0.05). Group IV nonfluoride toothpaste was found

statistically effective against C. albicans, S. sobrinus, L. casei (p < 0.01). Group V nonfluoride toothpaste was found statistically effective

against S. mutans, S. sobrinus, L. casei and A. naeslundii (p < 0.05). Group VI nonfluoride toothpaste was found ineffective against

all tested oral pathogens (p > 0.05). Group VII fluoride gel was found less effective C. albicans and S. sobrinus (p < 0.05). But Group

VIII zinc fluoride gel was found statistically ineffective against all tested oral pathogens (p > 0.05).

Conclusion: Despite gels were found ineffective in this in vitro study, they will be given more positive results in clinical usage and in

vivo studies. In vivo studies should be performed to investigate the antibacterial effects of toothpastes and fluoride gels.