Sickle cell anemia is a chronic congenital hemolytic anemia which courses with high feto-maternal morbidity and mortality, characterized with painful crises increasing in the third trimester. It usually commences with sickling crises in infancy period, and may result with chronic organ failure in childhood or early adulthood. We report here the case of 21 years old woman admitted at 39 weeks of pregnancy. In physical examination splenomegaly and in the demanded lab tests deep anemia (Hb 6.5 g/dl, Htc 17.6%), elevated conjugated and unconjugated bilirubin levels (4.2 mg/dl, 2.88 mg/dl), elevated LDH and RDW levels (1433 U/L, 30.2%) were detected. Although the patient, whose diagnosis was ascertained as "homozygote sickle cell anemia" in detailed investigations, was delivered 3550g male baby. She was 21 years old and the disease was asymptomatic till that age.