The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet

Seyithanoglu M., Oner-Iyidogan Y. , Dogru-Abbasoglu S., Tanrikulu-Kucuk S., Kocak H., Beyhan-Ozdas S., ...Daha Fazla

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.122, sa.2, ss.94-102, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 122 Konu: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/13813455.2015.1120753
  • Sayfa Sayıları: ss.94-102


Effects of curcumin (turmeric) and capsaicin (red pepper) on hepatic fat accumulation and fetuin-A expression in rats fed high-fat diet (HFD) is aimed to be investigated. Male Sprague-Dawley rats received HFD (60% of total calories from fat) and 0.15g capsaicin/kg HFD and/or 1.5g curcumin/kg HFD for 16 weeks. Hepatic AMPK, p-AMPK and fetuin-A expressions were determined by western blotting, liver lipid levels were measured with colorimetric methods and serum fetuin-A, insulin, leptin and adiponectin levels were detected using commercial ELISA kits. HFD increased hepatic lipid levels, fetuin-A expression and serum leptin, insulin and fetuin-A levels. Curcumin and capsaicin treatments significantly reduced hepatic fat accumulation and leptin levels; liver fetuin-A expression was decreased significantly by the curcumin treatment. Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation. The suppression of hepatic fetuin-A expression is observed to be especially sensitive to curcumin.