Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin


Berkarda B., Koyuncu H., Soybir G., Baykut F.

RESEARCH IN EXPERIMENTAL MEDICINE, cilt.198, ss.93-99, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 198 Konu: 2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1007/s004330050093
  • Dergi Adı: RESEARCH IN EXPERIMENTAL MEDICINE
  • Sayfa Sayıları: ss.93-99

Özet

A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hesperidin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.