Serum anti-mullerian hormone levels in the main phenotypes of polycystic ovary syndrome

Sahmay S., Atakul N., Oncul M. , Tuten A. , Aydogan B., Seyisoglu H. H.

European Journal of Obstetrics and Gynecology and Reproductive Biology, cilt.170, sa.1, ss.157-161, 2013 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 170 Konu: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.ejogrb.2013.05.019
  • Dergi Adı: European Journal of Obstetrics and Gynecology and Reproductive Biology
  • Sayfa Sayıları: ss.157-161


Objective To characterize the difference in circulating anti-Müllerian hormone (AMH) levels between the main polycystic ovary syndrome (PCOS) phenotypic groups and evaluate the role of AMH in predicting the severity of PCOS. Study design Cross-sectional, retrospective study. A total of 251 women were divided into four groups based on the main features of PCOS, as follows: Group 1 (polycystic ovarian morphology [PCOM]+/oligo-anovulation [OA]+/hyperandrogenism [HA]+), Group 2 (PCOM+/OA+/HA-), Group 3 (PCOM+/OA-/HA+), and Group 4 (PCOM-/OA+/HA+). AMH and other hormone levels were measured in serum. The main outcome was serum AMH concentrations in the main phenotypes of PCOS. Result(s) The mean serum AMH levels were 9.50 ± 6.1 ng/mL in Group 1; 8.02 ± 6.2 ng/mL in Group 2; 6.12 ± 3.6 ng/mL in Group 3; and 3.06 ± 2.4 ng/mL in Group 4. Circulating AMH levels in Group 1 (PCOM+/OA+/HA+) were three times higher than those in Group 4 (PCOM-/OA+/HA+). Conclusions The highest AMH levels were found in cases where all three main diagnostic criteria existed. AMH levels correlate best with PCOM. In addition, oligo-anovulation contributes to increased AMH levels. Hyperandrogenism criteria were found to have less influence on AMH levels. AMH levels seem to have a diagnostic role in determining the severity of PCOS. © 2013 Elsevier Ireland Ltd. All rights reserved.