Simultaneous Determination of Benzodiazepines and Ketamine from Alcoholic and Nonalcoholic Beverages by GC-MS in Drug Facilitated Crimes


Acikkol M. , Mercan S. , Karadayi S.

CHROMATOGRAPHIA, cilt.70, ss.1295-1298, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 70
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1365/s10337-009-1278-6
  • Dergi Adı: CHROMATOGRAPHIA
  • Sayfa Sayıları: ss.1295-1298

Özet

A GC-MS method with HP-5MS capillary column was developed for the simultaneous determination of underivatized flunitrazepam, clonazepam, alprazolam, diazepam and ketamine from drinks by extraction with chloroform: isopropanol 1:1 (v/v). All linearity ranges were between 50 and 1,000 mu g mL(-1) for all compounds both in beer and in peach juice. Limit of detection was between 1.3 and 34.2 mu g mL(-1), limit of quantification was between 3.9 and 103.8 mu g mL(-1), the range of recoveries was 73.0 and 112.6% for all drugs in both beverages. The reported method was sensitive, rapid, and suitable for the analysis of the spiked drinks as evidence of sexual assault and robbery phenomena.