Oxidative damage to nuclear DNA in streptozotocin-diabetic rat liver


Andican G. , Burcak G.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.32, ss.663-666, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 8
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.0305-1870.2005.04247.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Sayfa Sayıları: ss.663-666

Özet

1. Accumulating evidence suggests that oxidative and glycative stress is enhanced in diabetes. Oxidative stress induces DNA damage. In the present study, we assessed the 8-oxo-2'-deoxyguanosine (8-oxodG) content of DNA, an indicator of oxidative DNA damage, in streptozotocin (STZ)-induced diabetic (n=21) and control rats (n=18).