Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas

Creative Commons License

Mert A. , Tabak F. , Ozaras R. , Ozturk R. , Aki H., Aktuglu Y.

INTERNAL MEDICINE, cilt.43, sa.5, ss.436-439, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier


During the course of typhoid fever, the usual histologic finding of the liver is "nonspecific reactive hepatitis." Hepatic granuloma (HG) is a rare complication of typhoid fever. We present two cases of typhoid fever with HG and review the relevant literature. Case 1 (a 53-year-old female) was found to have both hepatic and splenic granulomas. This is the first case of typhoid fever with splenic granulomas in the English language literature. Case 2 (a 66-year-old male) developed granulomas in the bone marrow in addition to HG. It should be considered that typhoid fever may lead to granulomas in several organs.