Effects of methylprednisolone pulse therapy on insulin injections in patients with insulin-dependent diabetes mellitus

Satman I., Ficicioglu C., Karsidag K., Yilmaz T., Dincdag N., Koca F., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.38, ss.419-429, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 38 Konu: 4
  • Basım Tarihi: 1996
  • Sayfa Sayıları: ss.419-429


In this study we evaluated 31 insulin-dependent diabetes mellitus (IDDM) patients (ages 12.1+/-3.4 years, 18 males/13 females) who started on multiple subcutaneous insulin injections (MSII) within six weeks of diagnosis and achieved either complete (CR: no insulin requirement and near-normoglycemia for at least two weeks) or incomplete (ICR: minimum 50% decline in insulin requirement while maintaining near-normoglycemia for two weeks or more) remissions within the first 12 weeks of the MSII trial. Methylprednisolone pulse therapy (MP) was administered four times per day by IV bolus at a dose of 30 mg/kg (max. 1000 mg) on alternate days.