The plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in pre-eclampsia


Madazli R. , BENİAN A. , Aydin S., UZUN H. , Tolun N.

Journal of Obstetrics and Gynaecology, cilt.22, sa.5, ss.477-480, 2002 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Konu: 5
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1080/0144361021000003573
  • Dergi Adı: Journal of Obstetrics and Gynaecology
  • Sayfa Sayıları: ss.477-480

Özet

The aim of the study is to investigate the plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in normotensive and pre-eclamptic pregnancies. Peripheral venous blood samples were collected before labour (35.3 ± 1.1 and 34.2 ± 3.4 weeks for normotensive and pre-eclamptic, respectively) and placental tissues was obtained after delivery from 34 pre-eclampsia and 33 normotensive pregnancies. The mean plasma and placental levels of malondialdehyde were significantly higher, glutathione and superoxide dismutase levels were significantly lower in pre-eclamptic compared with normotensive patients (P < 0.01). The plasma and placental levels of malondialdehyde significantly increased, glutathione and superoxide dismutase significantly decreased with the increments in diastolic blood pressure. As a conclusion maternal circulating and placental tissue levels of lipid peroxides increase whereas antioxidants decrease in pre-eclampsia. The magnitude of oxidative stress and antioxidant changes correlate well with diastolic blood pressure.