Ow earlier studies have shown thar the flavonoid hesperidin inhibits tumor promotion in a two stage skin tumorigenesis protocol in CD-l mice. In this study hesperidin's significant protection (p<0.0001) against 12-0-tetradecanoylphorbol-13-acetate (TPA) induced edema in CD-I mouse ear will be presented. Hesperidin also afforded significant protection against TPA induced hyperplasia in the dorsal skin through multiple application prior to TPA. Protection by hesperidin was 93% of the epidermal thickness and 100% of the vertical cell layers The data also indicate the protective effect of hesperidin against TPA caused infiltration of neutrophils by 73%. These results suggest that hesperidin may possess potential as chemopreventive agent against tumor promoter induced inflammation and hyperplasia.