Association of APOE polymorphisms with disease severity in MS is limited to women

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Atıf İçin Kopyala

Kantarci O., Hebrink D., Achenbach S., Pittock S., Altintas A., Schaefer-Klein J., ...Daha Fazla

NEUROLOGY, cilt.62, ss.811-814, 2004 (SCI İndekslerine Giren Dergi)

• Cilt numarası: 62 Konu: 5
• Basım Tarihi: 2004
• Doi Numarası: 10.1212/01.wnl.0000113721.83287.83
• Dergi Adı: NEUROLOGY
• Sayfa Sayıları: ss.811-814

Özet

The authors studied the association of an exon 4 (E4* epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4* epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 ( p = 0.015) and had more favorable ranked severity scores than noncarriers ( p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.