Association of APOE polymorphisms with disease severity in MS is limited to women

Kantarci O., Hebrink D., Achenbach S., Pittock S., Altintas A., Schaefer-Klein J., ...More

NEUROLOGY, vol.62, no.5, pp.811-814, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 5
  • Publication Date: 2004
  • Doi Number: 10.1212/01.wnl.0000113721.83287.83
  • Title of Journal : NEUROLOGY
  • Page Numbers: pp.811-814

Abstract

The authors studied the association of an exon 4 (E4* epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4* epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 ( p = 0.015) and had more favorable ranked severity scores than noncarriers ( p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.