EFFECTS OF CARBAMAZEPINE AND VALPROATE ON BRAIN-STEM AUDITORY-EVOKED POTENTIALS IN EPILEPTIC CHILDREN


YUKSEL A., SENOCAK D., SOZUER D., KESKIN G., DIRICAN A., CENANI A., ...Daha Fazla

CHILDS NERVOUS SYSTEM, cilt.11, sa.8, ss.474-477, 1995 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 8
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1007/bf00334968
  • Dergi Adı: CHILDS NERVOUS SYSTEM
  • Sayfa Sayıları: ss.474-477

Özet

Brainstem auditory evoked potentials (BAEPs) were recorded in 18 epileptic children receiving carbamazepine and 10 epileptic children receiving valproate. BAEPs were recorded before the administration of antiepileptic drugs (AEDs) and 13 months later during which the children received AEDs. Statistical analysis of peak latencies and interpeak intervals of waves I-III-V were made. Carbamazepine treatment resulted in prolongation of peak latencies of waves I-III-V and interpeak intervals I-III and I-V. Valproate monotherapy, on the other hand, caused no consistent changes on BAEP. On the basis of these results we suggest that chronic carbamazepine therapy exerts a suppressive influence on the auditory pathways, both peripherally at the level of the cochlea and/or auditory nerve, and centrally at the brainstem.