Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The Istanbul Perspective


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Karakas Z., Koc B., Temurhan S., Elgun T., Karaman S., Asker G., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.32, sa.4, ss.344-350, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4274/tjh.2014.0204
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Sayfa Sayıları: ss.344-350

Özet

Objective: Alpha thalassemia syndromes are caused by mutations on one or more of the four a-globin genes. Mutations could be either more commonly deletional or non-deletional. As some deletions (3.7 and 4.2) cause alpha(+)-thalassemia, some cause (-20.5, MED, THAI, FIL) alpha(0)-thalassemia. The aim of this study was to determine alpha thalassemia mutations in patients with unsolved hypochromic microcytic anemia and to evaluate types of mutations.