Do sodium channel blockers have neuroprotective effect after onset of ischemic insult?


ATES O., CAYLI S. R. , Gurses I. , KARABULUT A. B. , YUCEL N., KOCAK A., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.29, sa.3, ss.317-323, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 29 Konu: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1179/016164107x159225
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Sayfa Sayıları: ss.317-323

Özet

Objective: Cerebral ischemia causes a series of pathophysiologic events that may result in cerebral infarct. Some neurons are more vulnerable to ischemia, particularly pyramidal neurons in the hippocampal CA1 region. Pharmacologic intervention for treatment of cerebral ischemia aims to counteract secondary neurotoxic events or to interrupt the progression of this process. In the present study, we compare the neuroprotective effects of sodium channel blockers (mexiletine, riluzole and phenytoin) and investigate whether they have neuroprotective effect when given after ischemic insult.