Continuous hyperfractionated accelerated radiotherapy in the treatment of high-grade astrocytomas

Bese N., Uzel O. , Turkan S., Okkan S.

RADIOTHERAPY AND ONCOLOGY, cilt.47, sa.2, ss.197-200, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Konu: 2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0167-8140(97)00233-8
  • Sayfa Sayıları: ss.197-200


Between May 1993 and January 1995, 36 patients with high-grade astrocytomas were treated with 1.05 Gy continuous hyperfractionated accelerated radiotherapy three times daily to a total target dose of 59.85 Gy in 19 days with 6-h intervals. The median age of the patients was 51 years and the median follow-up was 58 weeks. The median survival rate was 58 weeks and the cumulative survival rare was 22% at 2 years, No severe toxicity occurred in patients treated with this fractionation scheme. These results suggest that continuous hyperfractionated accelerated radiotherapy is an altered fractionation schedule for: high-grade astrocytomas with tolerable acute toxicity and survival rates comparable to conventional fractionation and to other altered fractionation schedules. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.