Subacute sclerosing panencephalitis(SSPE) is a slow infection with measles virus that causes progressive inflammation and sclerosis of the brain. It is the rarely seen late complication of measles, mostly occuring at 5-15 years of age. The incidence in males is twice as much as females. SSPE is neurodegenerative disease which presents typically with changes in behaviour and progressive myoclonic activity followed by diffuse neurological disorsers. The disease is rapidly progressive and the survival time is approximately 6-24 months after the occurrence of first symptoms. In this study, 19 cases of SSPE, diagnosed and treated in our clinic between 1998-2003, are presented. 14 of the patients were male and 5 were female. Average was 6.3±2.5 years (2-10 years) and the mean age of measles infection was 1.3±0.9 years (3 months-2.5 years). 6 of the patients were unvaccinated. Most of the patients presented at stage 2. On admission, ataxia and gait disorder was seen in 46%, behavioral changes and disarthria 38%, amnesia and head-drop 30%, weakness, convulsions, headache and involuntary movements 23%, urinary incontinence, myoclonic jerks, loss of consciousness 15% and dysphagia 7.6%. 12 of the patients were treated with Isoprinosin and Interferon, 5 patients only Isoprinosin and 2 patients Interferon. 4 of them died approximately 7 months after diagnosis. This study is done to evaluate the clinical course of SSPE and to compare the results with literature knowledge.