SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL PROPERTIES OF NOVEL PIPERIDINOLYL-, PIPERIDINYL-, AND PIPERAZINYL-SUBSTITUTED NAPHTHOQUINONE COMPOUNDS AND THEIR REACTIONS WITH SOME THIOLS


Ibis C., Ayla S. , Bahar H., Stasevych M. V. , Komarovska-Porokhnyavets O., Novikov V.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.190, sa.9, ss.1422-1433, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 190 Konu: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1080/10426507.2014.986268
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Sayfa Sayıları: ss.1422-1433

Özet

Nucleophillic substitution reactions of 2,3-dichloro-1,4-naphthoquinone (1) were studied using a variety of piperidinol, piperidine, and piperazine derivatives. The N-substituted compounds were treated with some thiols and N,S-substituted compounds were formed. The structures of the new products were characterized by spectroscopic methods (H-1 NMR, C-13 NMR, MS) and elemental analysis. The novel compounds were evaluated for their antibacterial and antifungal activity.