The effect of LKB1 on the PI3K/Akt pathway activation in association with PTEN and PIK3CA in HNC


Ekizoglu S. , Dogan S., Ulker D., Seven D., Gozen E. D. , Karaman E. , et al.

CLINICAL OTOLARYNGOLOGY, cilt.40, ss.622-628, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 40 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/coa.12427
  • Dergi Adı: CLINICAL OTOLARYNGOLOGY
  • Sayfa Sayısı: ss.622-628

Özet

Objective: PI3K/Akt signalling pathway is frequently activated in several types of cancer. However, activator molecules have not been analysed systematically in HNSCC. The aim of this study was to investigate upstream activators and inhibitors of this pathway.