Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death


Imeryuz N., Tahan V., Sonsuz A., Eren F., Uraz S., Yuksel M., et al.

JOURNAL OF HEPATOLOGY, cilt.47, ss.851-859, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 47 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jhep.2007.06.018
  • Dergi Adı: JOURNAL OF HEPATOLOGY
  • Sayfa Sayısı: ss.851-859

Özet

Background/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).