Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population


Creative Commons License

Cakmak H. A. , Bayoglu B. , Durmaz E. , Can G. , Karadag B., Cengiz M. , ...Daha Fazla

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.15, ss.196-203, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/akd.2014.5285
  • Dergi Adı: ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
  • Sayfa Sayıları: ss.196-203

Özet

Objective: Coronary artery disease (CAD), which develops from complex interactions between genetic and enviromental factors, is a leading cause of death worldwide. Based on genome-wide association studies (GWAS), the chromosomal region 9p21 has been identified as the most relevant locus presenting a strong association with CAD in different populations. The aim of the present study was to investigate the association of two SNPs on chromosome 9p21 on susceptibility to CAD and the effect of these SNPs along with cardiovascular risk factors on the severity of CAD in the Turkish population.