The roles of the GPX1 Pro198Leu and OGG1 Ser326Cys variants in coronary artery disease


Bayoglu B. , Cakmak H. A. , Yuksel H., Kurt E., Cengiz M.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.41, ss.44-50, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 41
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/tjb-2016-0007
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.44-50

Özet

Objective: Coronary artery disease (CAD) is caused by plaque formation on inner walls of coronary arteries. Glutathione peroxidase-1 (GPX1), prevents oxidative damage by detoxifying hydrogen and lipid peroxides. GPX1 Pro198Leu polymorphism results in oxidant/antioxidant imbalance. 8-oxoguanine DNA glycosylase-1 (OGG1) is the key enzyme in DNA repair pathway. OGG1 Ser326Cys polymorphism leads to 8-oxoG accumulation and may play a role in cardiovascular diseases. Thus, our study aims to investigate GPX1 Pro198Leu and OGG1 Ser326Cys polymorphisms in CAD patients and the possible relationship of genotypes with serum lipids and CAD severity.