The effects of corticosteroid on tissue lactoferrin in patients with nasal polyposis


Acioglu E. , Yigit O. , Alkan Z., Azizli E., Gelisgen R. , Uzun H.

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, cilt.26, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 26 Konu: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.2500/ajra.2012.26.3735
  • Dergi Adı: AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

Özet

Background: Although, lactoferrin (LF) is the second most important antimicrobial and anti-inflammatory peptide after lysozyme in upper respiratory tract, little is known about its role in chronic rhinosinusitis (CRS). Recent studies pronounced that LF levels were significantly reduced in CRS with nasal polyposis (NP) compared with other subgroups. However, effects of systemic corticosteroid (CS) treatment, which is currently the main NP treatment modality, and subsequent surgical intervention on LF levels are still not known. This study was designed to evaluate the effects of CS treatment and surgical intervention on LF levels in patients with NP.