New NH-substituted 1,4-naphtho- and 1,4-benzo- quinones: Synthesis, characterization and potential antiproliferative effect against MDA-MB-231 cells


KAÇMAZ A. , HAMURCU Z.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.193, ss.831-839, 2018 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 193 Konu: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/10426507.2018.1514503
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Sayfa Sayısı: ss.831-839

Özet

Eleven new alkyl and aryl amino quinones were synthesized from quinones (2,3-dibromo-1,4-naphthoquinone 1, 2-bromo-1,4-naphthoquinone 2, p-benzoquinone 3 or 2,6-dichloro-1,4-benzoquinone 8) with primary amines. The structures of all compounds were characterized by spectroscopic technics and elemental analysis. The structure of 2-((6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)methylamino)-3-bromonaphthalene-1,4-dione (5a) was established by single crystal diffraction. 2-(2-(Ethylthio)ethylamino)naphthalene-1,4-dione (6b) was found to have noteworthy antiproliferative effect against MDA-MB-231 cells.