Estrogen-induced myelotoxicity in dogs: A review


Sontas H. , Dokuzeylu B., Turna O., Ekici H.

CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE, cilt.50, ss.1054-1058, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 50 Konu: 10
  • Basım Tarihi: 2009
  • Dergi Adı: CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
  • Sayfa Sayıları: ss.1054-1058

Özet

Exogenous estrogens used for therapeutic purposes or endogenous estrogen sources such as functional Sertoli cell or ovarian granulosa cell tumors may cause bone marrow toxicity in dogs. The condition is characterized by hematologic abnormalities including thrombocytopenia, anemia, and leukocytosis or leukopenia. Despite intensive therapy with blood or platelet-rich transfusions, broad-spectrum antibiotics, steroids, and bone marrow stimulants, prognosis is unfavorable. Due to the the risk of stimulating the development of uterine diseases and the potential for inducing aplastic anemia, estrogen use in dogs is best avoided where possible. This paper describes the causes of estrogen-induced myelotoxicity the clinical presentation of the patients, the diagnosis, and the treatment options in the dog.