Association between genetic polymorphism in DNA repair genes and risk of B-cell lymphoma

Baris S., Celkan T. T. , Batar B., Guven M. , Ozdil M., Ozkan A. , ...Daha Fazla

Pediatric Hematology and Oncology, cilt.26, sa.6, ss.467-472, 2009 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26 Konu: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/08880010903096201
  • Dergi Adı: Pediatric Hematology and Oncology
  • Sayfa Sayıları: ss.467-472


Objectives: The authors evaluated the possible effect of DNA repair genes, XPD (Xeroderma pigmentosum group D) codon (312 and 751) and XRCC1 (X-ray repair cross-complementing group 1) codon (194 and 399) SNPs (single-nucleotide polymorphisms) on the risk of childhood B-cell lymphoma. Methods: The polymorphisms were analyzed in 33 patients with BL cases and in 52 healthy, age-matched controls using PCR-RFLP method. Results: The authors observed no association between variation in the XPD codon Asp312Asn, Lys751Gln, and XRCC1 codon Arg399Gln polymorphisms and B-cell lymphoma for any parameter. In contrast, tryptophan allele frequency in control and patient groups was 0.10 and 0.03 respectively (p =.04). The frequency of XRCC1 194Arg/Trp genotype in B-cell lymphoma was significantly lower than that in controls (p =.005). No significant relationship was found between genotypes and stage, lactate dehydrogenase, or bone marrow involvement. Conclusions: XRCC1 194Trp allele may be associated with a protective effect against development of childhood B-cell lymphoma. However, these results were based on a small number of case and further studies should be done. Copyright © Informa Healthcare USA, Inc.