The effects of vitamin E on lipid peroxidation, nitric oxide production, and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury


Gumustas K. , Guzeyli F. M. , Atukeren P. , Sanus G. Z. , Kemerdere R., Tanriverdi T. , ...Daha Fazla

TURKISH NEUROSURGERY, cilt.17, sa.2, ss.78-82, 2007 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 2
  • Basım Tarihi: 2007
  • Dergi Adı: TURKISH NEUROSURGERY
  • Sayfa Sayıları: ss.78-82

Özet

OBJECTIVES: Recent studies have revealed that nitric oxide (NO) in concert with lipid peroxidation (LP) may play an important role in pathophysiological mechanism(s) of cerebral ischemia. In addition, hyperglycemia exaggerates the pathological changes during cerebral ischemia. The purpose of this study was to investigate the effects of vitamin E (VE) on LP, NO production, and superoxide dismutase (SOD) expression in hyperglycemic rats after cerebral ischemia-reperfusion injury.