The aim of this paper is to study an epidemiological aspect of fatalities from motor vehicle accidents in Jeddah, Saudi Arabia. All fatal accidents that occurred in Jeddah between 1 January and 31 December 1987 are analyzed. The death rates per hundred million vehicle kilometers of travel, per 100,000 registered motor vehicles, and per 100,000 resident population in 1987 were about 1.87, 19.7, and 26.5, respectively. An attempt is made to use international death rates to compare Jeddah with other countries. The figures reveal higher death rates per vehicle travel and per resident population but lower rate per registered vehicle than in some industrialized countries. An additional attempt was made to estimate the cost of road traffic fatalities in Jeddah, which is an extremely difficult task due to lack of reliable data. This study shows that the cost of 1987 road fatalities in Jeddah is estimated to be 648.7 million Saudi Riyals (US$172.5 million).