Regression of Cardiac Rhabdomyomas in a Neonate after Everolimus Treatment


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Bornaun H., Oztarhan K., Erener-Ercan T., Dedeoglu R. , Tugcu D., Aydogmus C., ...Daha Fazla

CASE REPORTS IN PEDIATRICS, 2016 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası:
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1155/2016/8712962
  • Dergi Adı: CASE REPORTS IN PEDIATRICS

Özet

Cardiac rhabdomyoma often shows spontaneous regression and usually requires only close follow-up. However, patients with symptomatic inoperable rhabdomyomas may be candidates for everolimus treatment. Our patient had multiple inoperable cardiac rhabdomyomas causing serious left ventricle outflow-tract obstruction that showed a dramatic reduction in the size after everolimus therapy, a mammalian target of rapamycin (mTOR) inhibitor. After discontinuation of therapy, an increase in the diameter of masses occurred and everolimus was restarted. After 6 months of treatment, rhabdomyomas decreased in size and therapy was stopped. In conclusion, everolimus could be a possible novel therapy for neonates with clinically significant rhabdomyomas.