Serum microRNA expression in pregnancies with preeclampsia


Gunel T. , Zeybek Y. G. , Akcakaya P., Kalelioglu I., Benian A., Ermis H., et al.

GENETICS AND MOLECULAR RESEARCH, cilt.10, ss.4034-4040, 2011 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 10 Konu: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.4238/2011.november.8.5
  • Dergi Adı: GENETICS AND MOLECULAR RESEARCH
  • Sayfa Sayısı: ss.4034-4040

Özet

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.