Ethylene Glycol Induced Hyperoxaluria Increases Plasma and Renal Tissue Asymmetrical Dimethylarginine in Rats: A New Pathogenetic Link in Hyperoxaluria Induced Disorders


Aydin H., Yencilek F., Mutlu N., Comunoglu N. , Koyuncu H. H. , Sarica K.

JOURNAL OF UROLOGY, cilt.183, ss.759-764, 2010 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 183 Konu: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.juro.2009.09.076
  • Dergi Adı: JOURNAL OF UROLOGY
  • Sayfa Sayısı: ss.759-764

Özet

Purpose: The pathogenesis of kidney stones remains elusive. There is some evidence that hyperoxaluria may effect vascular endothelium and many studies link renal stones to atherosclerosis. Also, renal vascular endothelial cells regulate proximal tubular epithelial cell function. We determined the effect of hyperoxaluria on plasma and tissue levels of asymmetrical dimethylarginine. The secondary aim was to determine the effect of verapamil on asymmetrical dimethylarginine.