Cox-2 gene variants in migraine

Dasdemir S. , Cetinkaya Y., GENCER M., Ozkok E., Aydin M., Cakmakoglu B.

GENE, cilt.518, ss.292-295, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 518 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.gene.2012.12.110
  • Dergi Adı: GENE
  • Sayfa Sayısı: ss.292-295


Purpose: Migraine is a multifactorial and complex disorder, and any clear diagnostic marker to assess the status of the migraineurs has not been established, yet. Nonsteroidal anti-inflammatory drugs reduce production of prostanoids including PGE2 by inhibiting COX-1 and/or COX-2, and thereby suppress inflammatory pain in patients suffering from rheumatoid arthritis, osteoarthritis, and migraine. Thus, COX-2 regulation is important in the pathogenesis and treatment of migraine. We prospectively investigated COX-2-765G -> C and COX-2-1195A -> G gene polymorphisms which may account for an increased risk of migraine.