LNCaP progression model of human prostate cancer: Androgen-independence and osseous metastasis


Thalmann G., Sikes R., Wu T., Degeorges A., Chang S., Ozen M. , et al.

PROSTATE, cilt.44, ss.91-103, 2000 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 44 Konu: 2
  • Basım Tarihi: 2000
  • Dergi Adı: PROSTATE
  • Sayfa Sayısı: ss.91-103

Özet

BACKGROUND. Clinically, the lethal phenotypes of human prostate cancer are characterized by their progression to androgen-independence and their propensity to form osseous metastases. We reported previously on the establishment of androgen-independent (AI) human prostate cancer cell lines derived from androgen-dependent (AD) LNCaP cells, with androgen independence defined as the capability of prostate cancer cells to grow in castrated hosts. One of the sublines, C4-2, was found to be AI, highly tumorigenic, and metastatic, having a proclivity for metastasis to the bone.