PHARMACOKINETICS OF COLCHICINE IN PEDIATRIC AND ADULT PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER


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Berkun Y., Wason S., Brik R., Butbul Y., Ben-Chetrit E., Hashkes P. J. , et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, cilt.25, ss.1121-1130, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 25 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/039463201202500429
  • Dergi Adı: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
  • Sayfa Sayısı: ss.1121-1130

Özet

This study sought to determine the appropriate starting dose of colchicine in children aged 2 to 4 years with familial Mediterranean fever (FMF) based on steady-state pharmacokinetics in pediatric patients with FMF >= 2 to <16 years and adult patients with FMF >= 16 to <= 65 years. Outpatients received colchicine for 90 days starting with a fixed dose for 14 days (blood sampling days 14 and 15). After starting doses of colchicine (0.6 mg/day [>= 2 to <4 years], 0.9 mg/day [>= 4 to <6 years], 0.9 mg/day [>= 6 to <12 years], 1.2 mg/day [>= 12 to <16 years], and 1.2 mg/day [>= 16 to <= 65 years]), the observed steady-state pharmacokinetic parameters were comparable across age groups, despite the higher doses of colchicine on a mg/kg/day basis in the younger age groups. An exception occurred with once-daily colchicine, whereby mean C-max for colchicine was higher in patients 4 to <6 years (9.4 ng/mL) compared with the younger and older age groups (6.1-6.7 ng/mL). Mean AUC(0_24h) values in children 2 to <4, 6 to <12, and 12 to <16 years were similar to those in adults. However, mean AUC(0_24h) values in children 4 to <6 years were 25% higher than those observed in adults. The results show that the recommended starting dose for children 2-4 years and 4-6 years should be 0.6 mg/day (half the US adult dose). Children aged 6 to <12 years should receive 0.9 mg/day (i.e. three-quarters of the US adult dose). The safety of colchicine in children 2 to <4 years was comparable to that in older children and adults.