First-trimester maternal serum metastin levels, chitotriosidase activity and uterine artery doppler findings in preeclampsia Preeklampsi olgularinda birinci trimester maternal serum metastin düzeyi, kitotriozidaz aktivitesi ve uterin arter doppler bulgulari


Madazli R. , Bulut B., Aydin B., Demirayak G., KUCUR M.

Turkiye Klinikleri Jinekoloji Obstetrik, cilt.22, sa.4, ss.211-215, 2012 (Diğer Kurumların Hakemli Dergileri) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Konu: 4
  • Basım Tarihi: 2012
  • Dergi Adı: Turkiye Klinikleri Jinekoloji Obstetrik
  • Sayfa Sayıları: ss.211-215

Özet

Objective: To investigate the difference of first trimester (11-14 weeks) serum levels of metastin, chitotriosidase activity and UtA Doppler findings between women who subsequently develop preeclampsia and controls. Material and Methods: Study was designed as a retrospective case-control study of propectively collected data. Pregnancies that were followed at our clinic had UtA Doopler examination and serum samples were collected during 11-14 weeks screening. 30 healthy pregnant women and 31 women with preeclampsia that delivered during September 2008-May 2010 were included in the study. Maternal serum metastin, chitotriosidase and UtA Doppler findings were compared. Results: Mean maternal serum metastin (1554±385 pmol/L vs 1995±375 pmol/L, p=0.000) levels were significantly lower in women who subsequently developed preeclampsia than controls. Mean maternal serum chitotriosidase activity (681.6±248.3 nmol/mL/h vs 527.7±223.1 nmol/mL/h, p=0.014) and UtA PI (1.93±0.40 vs 1.27±0.35, p=0.000) was significantly higher in women who subsequently developed preeclampsia than controls. The areas under the curve equal to 0.896, 0.797 and 0.681 (p=0.000, p=0.000 and p=0.015) for UtA PI, metastin, and chitotriosidase respectively were determined for the prediction of preeclampsia. Conclusion: First trimester maternal serum metastin levels, chitotriosidase activity and UtA PI values are altered in women destined to become preeclamptic. UtA Doppler and metastin, have a potential to be used as a first trimester prediction test for preeclampsia. Copyright © 2012 by Türkiye Klinikleri.