Priming with rocuronium Rokuronyumla priming uygulanmasi

Salihoglu Z. , Karaca S., Kose Y.

Turk Anesteziyoloji ve Reanimasyon, cilt.27, ss.492-496, 1999 (Diğer Kurumların Hakemli Dergileri) identifier

  • Cilt numarası: 27
  • Basım Tarihi: 1999
  • Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
  • Sayfa Sayıları: ss.492-496


In this study, we aimed to compare intubation conditions, haemodynamic parameters and onset times of neuromuscular block using rocuronium with or with-out priming dose. After ethics committee approval and informed consent, we studied 40 ASA group I-II patients allocated randomly into two groups patients receiving priming dose were the study group (n=20), and the patients not receiving priming were the control group (n=20). Neuromuscular monitorization was provided by TOF Guard with single titch stimulation in both groups. In the operation room, all patients in both group were premedicated with midazolam 0.05 mg/kg IV. In the study group, 0.6 mg/kg rocuronium was administered as priming dose. After a four minute waiting period, anaesthesia induction was started and 0.54 mg/kg rocuronium was given thereafter for intubation. In the control group, priming dose was not used and after the same induction, rocuronium was given once in a dose of 0.06 mg/kg. When single twitch response was inhibited 95%, it was accepted that the effect of muscle relaxant has begun, and tracheal intubation was performed. Haemodynamic values such as mean arterial pressure (MAP) and heart rate (HR) were recorded preoperatively, and after the intubation. Intubation conditions were scored by a modified Domaoal scale. There was no significant difference between two groups in demographic data, mean arterial pressure and heart rate. Intubation conditions were excellent in both groups. The average time of 95 % block of single twitch response in the study group and control group were 43.25 ± 14.27 sec and 64.75 ± 13.12 sec respectively (p<0.05). In conclusion, priming of rocuronium is effective, reliable and it may be a good alternative to succinylcholine.