Looking for our ten years results for coronary heart disease and ischemic stroke group for the standpoint of haemostasis

Ulutin T. , Sönmez H., Domaniç N., İnce B. , Bayram G. , Ural D., ...Daha Fazla

Turkish Journal of Haematology, cilt.19, sa.2, ss.255-263, 2002 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 19 Konu: 2
  • Basım Tarihi: 2002
  • Dergi Adı: Turkish Journal of Haematology
  • Sayfa Sayıları: ss.255-263


To evaluate the role the coagulation and fibrinolysis abnormalities in the pathogenesis of ischemic stroke of undetermined etiology, we assayed plasma concentration of fibrinopeptide-A and thrombin-antithrombin III complex, both sensitive markers for thrombin activation and fibrin formation, and D-dimer, a marker of plasmin activity and fibrinolysis. Hemostatic markers were measured in 32 patients with acute stroke and 20 patients with chronic stroke, and compared with 21 normal subjects. Fibrinopeptid-A and thrombin-antithrombin III complex levels were not elevated significantly, whereas the D-dimer level was markedly raised in acute (p<0.001) and chronic (p< 0.05) phases of ischemic stroke in comparison with the control group. Prolonged elevation of D-dimer concentration suggests that hemostatic abnormalities have a primary role in the pathogenesis of ischemic stroke. The measurement of D-dimer concentration may help to better decide the indications for therapy of the patients with ischemic stroke of undetermined etiology.