Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats


Tahan G., Akin H., Aydogan F., Ramadan S. S. , Yapicier O., Tarcin O., ...Daha Fazla

CANADIAN JOURNAL OF SURGERY, cilt.53, sa.5, ss.313-318, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 53 Konu: 5
  • Basım Tarihi: 2010
  • Dergi Adı: CANADIAN JOURNAL OF SURGERY
  • Sayfa Sayıları: ss.313-318

Özet

Background: Hepatic stellate cells, the main mediators in the pathogenesis of fibrosis, are triggered by free radicals and produce collagen. Melatonin is a powerful physiologic scavenger of hydroxyl radicals. It is also involved in the inhibitory regulation of the collagen content in tissue. There is no effective treatment available for liver fibrosis. Our objective was to evaluate the effects of melatonin on liver fibrosis induced by bile-duct ligation (BDL) in rats.