Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers

Ertik O. , Saçan Ö. , Kabasakal L., Şener G., Yanardağ R.

Experimed, cilt.11, sa.1, ss.27-32, 2021 (Hakemli Üniversite Dergisi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Konu: 1
  • Basım Tarihi: 2021
  • Dergi Adı: Experimed
  • Sayfa Sayıları: ss.27-32


Objective: Diabetes mellitus is a metabolic disease of global importance.

It affects many people by reducing their quality of life

and even causing death. Therefore, research on diabetes mellitus

maintains its popularity and continues to develop. Chard (Beta

vulgaris L. var. cicla) is commonly used in diets and is known to

have alternative hypoglycemic effects in diabetic individuals. This

study investigated the protective effects of chard on glycoproteins

(hexose, hexosamine, fucose, and sialic acid) and the advanced oxidation

protein product levels in diabetic rats’ livers.

Materials and Methods: For this experiment, male Sprague–Dawley

rats were separated into three groups: the control; Streptozotocin

(STZ)-induced diabetic rats; and STZ-induced diabetic + chard

extract. Fourteen days after diabetes induction, chard extract

(2 g/kg/day, gavage) was administered for 45 days. On day 60, liver

samples were collected, and 10% (w/v) homogenate was prepared

for the analysis of glycoprotein components and advanced oxidation

protein products.

Results: Levels of glycoprotein parameters that include hexose,

hexosamine, fucose, and sialic acid, as well as advanced oxidation

protein product levels increased in the diabetic group. Chard extract

administration curatively reverted the altered biochemical


Conclusion: From the results obtained, it can be suggested that

chard extract has a protective effect on the diabetic livers of rats.