Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults


Yuzbasiogullari A. B. , Komurcu-Bayrak E., Onat A., Can G. , Mononen N., Laaksonen R., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.24, sa.5, ss.326-333, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14744/anatoljcardiol.2020.57736
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Sayfa Sayıları: ss.326-333

Özet

Objective: TCF7L2 is a repressor and transactivator of genes, and its variants are strongly associated with diabetes. This study aimed to evaluate the sex-specific relationship between the most common TCF7L2 gene variants (-98368G>T, rs12255372 and -47833C>T, rs7903146) with diabetes and coronary heart disease in Turkish Adult Risk Factor (TARF) Study.